Neuroprotective Strategies in Alzheimer’s Disease

Por Longo, Frank M., Massa, Stephen M.
Publicado em 2004

The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis

Por Bernabeu, Ramon O, Longo, Frank M
Publicado em 2010

Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis

Por Meeker, Rick B., Poulton, Winona, Clary, Gillian, Schriver, Michael, Longo, Frank M.
Publicado no Exp Neurol (2015)

Suppression of immunodeficiency virus-associated neural damage by the p75 neurotrophin receptor ligand, LM11A-31, in an in vitro feline model

Por Meeker, Rick B., Poulton, Winona, Feng, Wen-hai, Hudson, Lola, Longo, Frank M.
Publicado em 2011

Signaling Through Rho GTPase Pathway as Viable Drug Target

Por Lu, Qun, Longo, Frank M., Zhou, Huchen, Massa, Stephen M., Chen, Yan-Hua
Publicado em 2009

E-cadherin promotes retinal ganglion cell neurite outgrowth in a Protein Tyrosine Phosphatase-mu dependent manner

Por Oblander, Samantha A., Ensslen-Craig, Sonya E., Longo, Frank M., Brady-Kalnay, Susann M.
Publicado em 2007

Amelioration of Cisplatin-Induced Experimental Peripheral Neuropathy by a Small Molecule Targeting p75(NTR)

Por Friesland, Amy, Weng, Zhiying, Duenas, Maria, Massa, Stephen M., Longo, Frank M., Lu, Qun
Publicado no Neurotoxicology (2014)

A Common Motif Targets Huntingtin and the Androgen Receptor to the Proteasome

Por Chandra, Shweta, Shao, Jieya, Li, Jennifer X., Li, Mei, Longo, Frank M., Diamond, Marc I.
Publicado em 2008

The Bdnf Val68 to Met Polymorphism Increases Compulsive Alcohol Drinking In Mice Which Is Reversed By TrkB Activation

Por Warnault, Vincent, Darcq, Emmanuel, Morisot, Nadege, Phamluong, Khanhky, Wilbrecht, Linda, Massa, Stephen M., Longo, Frank M., Ron, Dorit
Publicado no Biol Psychiatry (2015)

The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking

Por Darcq, Emmanuel, Morisot, Nadege, Phamluong, Khanhky, Warnault, Vincent, Jeanblanc, Jerome, Longo, Frank M., Massa, Stephen M., Ron, Dorit
Publicado no J Neurosci (2016)

ANTI-CANCER DRUG INDUCED NEUROTOXICITY AND IDENTIFICATION OF RHO PATHWAY SIGNALING MODULATORS AS POTENTIAL NEUROPROTECTANTS

Por James, Sarah E., Burden, Hubert, Burgess, Russell, Xie, Youmei, Yang, Tao, Massa, Stephen M., Longo, Frank M., Lu, Qun
Publicado em 2008

A Small Molecule p75(NTR) Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression

Por Simmons, Danielle A., Knowles, Juliet K., Belichenko, Nadia P., Banerjee, Gargi, Finkle, Carly, Massa, Stephen M., Longo, Frank M.
Publicado em 2014

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury

Por Xu, Bin, Park, Dongsun, Ohtake, Yosuke, Li, Hui, Hayat, Umar, Li, Junjun, Selzer, Michael E., Longo, Frank M., Li, Shuxin
Publicado no Neurobiol Dis (2014)

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

Por Massa, Stephen M., Yang, Tao, Xie, Youmei, Shi, Jian, Bilgen, Mehmet, Joyce, Jeffrey N., Nehama, Dean, Rajadas, Jayakumar, Longo, Frank M.
Publicado em 2010

Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

Por Faizi, Mehrdad, Bader, Patrick L, Saw, Nay, Nguyen, Thuy-Vi V, Beraki, Simret, Wyss-Coray, Tony, Longo, Frank M, Shamloo, Mehrdad
Publicado em 2012

A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome

Por Schmid, Danielle A., Yang, Tao, Ogier, Michael, Adams, Ian, Mirakhur, Yatin, Wang, Qifang, Massa, Stephen M., Longo, Frank M., Katz, David M.
Publicado em 2012

A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease

Por Simmons, Danielle A., Belichenko, Nadia P., Yang, Tao, Condon, Christina, Monbureau, Marie, Shamloo, Mehrdad, Jing, Deqiang, Massa, Stephen M., Longo, Frank M.
Publicado em 2013

ProNGF Induces p75-Mediated Death of Oligodendrocytes following Spinal Cord Injury

Por Beattie, Michael S., Harrington, Anthony W., Lee, Ramee, Kim, Ju Young, Boyce, Sheri L., Longo, Frank M., Bresnahan, Jacqueline C., Hempstead, Barbara L., Yoon, Sung Ok
Publicado em 2002

Oral Administration of a Small Molecule Targeted to Block proNGF Binding to p75 Promotes Myelin Sparing and Functional Recovery after Spinal Cord Injury

Por Tep, Chhavy, Lim, Tae Hee, Ko, Pyung On, Getahun, Sami, Ryu, Jae Cheon, Goettl, Virginia M., Massa, Stephen M., Basso, Michele, Longo, Frank M., Yoon, Sung Ok
Publicado em 2013

The p75 Neurotrophin Receptor Promotes Amyloid-β(1-42)-Induced Neuritic Dystrophy In Vitro and In Vivo

Por Knowles, Juliet K., Rajadas, Jayakumar, Nguyen, Thuy-Vi V., Yang, Tao, LeMieux, Melburne C., Vander Griend, Lilith, Ishikawa, Chihiro, Massa, Stephen M., Wyss-Coray, Tony, Longo, Frank M.
Publicado em 2009