A Small Molecule p75(NTR) Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression

Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant signaling through the neurotrophin receptor p75 (p75(NTR)). Thus, modulating p75(NTR) signaling is considered a pr...

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Autores principales: Simmons, Danielle A., Knowles, Juliet K., Belichenko, Nadia P., Banerjee, Gargi, Finkle, Carly, Massa, Stephen M., Longo, Frank M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143160/
https://ncbi.nlm.nih.gov/pubmed/25153701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102136
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