Small Molecule p75(NTR) Ligands Reduce Pathological Phosphorylation and Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in AβPP(L/S) Transgenic Mice

The p75 neurotrophin receptor (p75(NTR) ) is involved in degenerative mechanisms related to Alzheimer’s disease (AD). In addition, p75(NTR) levels are increased in AD and the receptor is expressed by neurons that are particularly vulnerable in the disease. Therefore, modulating p75(NTR) function may...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Nguyen, Thuy-Vi V., Shen, Lin, Griend, Lilith Vander, Quach, Lisa N., Belichenko, Nadia P., Saw, Nay, Yang, Tao, Shamloo, Mehrdad, Wyss-Coray, Tony, Massa, Stephen M., Longo, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278429/
https://ncbi.nlm.nih.gov/pubmed/24898660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-140036
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