A small molecule p75(NTR) ligand normalizes signalling and reduces Huntington’s disease phenotypes in R6/2 and BACHD mice

Decreases in the ratio of neurotrophic versus neurodegenerative signalling play a critical role in Huntington’s disease (HD) pathogenesis and recent evidence suggests that the p75 neurotrophin receptor (NTR) contributes significantly to disease progression. p75(NTR) signalling intermediates substant...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Simmons, Danielle A., Belichenko, Nadia P., Ford, Ellen C., Semaan, Sarah, Monbureau, Marie, Aiyaswamy, Sruti, Holman, Cameron M., Condon, Christina, Shamloo, Mehrdad, Massa, Stephen M., Longo, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418739/
https://ncbi.nlm.nih.gov/pubmed/28171570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw316
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