A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease

Loss of neurotrophic support in the striatum caused by reduced brain-derived neurotrophic factor (BDNF) levels plays a critical role in Huntington's disease (HD) pathogenesis. BDNF acts via TrkB and p75 neurotrophin receptors (NTR), and restoring its signaling is a prime target for HD therapeut...

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Bibliografiske detaljer
Main Authors: Simmons, Danielle A., Belichenko, Nadia P., Yang, Tao, Condon, Christina, Monbureau, Marie, Shamloo, Mehrdad, Jing, Deqiang, Massa, Stephen M., Longo, Frank M.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841443/
https://ncbi.nlm.nih.gov/pubmed/24285878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1310-13.2013
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