Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function. Correlations between altered BDNF expression and/or function and mechanism(s) underlying numerou...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Massa, Stephen M., Yang, Tao, Xie, Youmei, Shi, Jian, Bilgen, Mehmet, Joyce, Jeffrey N., Nehama, Dean, Rajadas, Jayakumar, Longo, Frank M.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2010
Sujets:
Technical Advance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860903/
https://ncbi.nlm.nih.gov/pubmed/20407211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41356
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