Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β

Passive immunization with an antibody directed against the N terminus of amyloid β (Aβ) has recently been reported to exacerbate cerebral amyloid angiopathy (CAA)-related microhemorrhage in a transgenic animal model. Although the mechanism responsible for the deleterious interaction is unclear, a di...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Racke, Margaret M., Boone, Laura I., Hepburn, Deena L., Parsadainian, Maia, Bryan, Matthew T., Ness, Daniel K., Piroozi, Kathy S., Jordan, William H., Brown, Donna D., Hoffman, Wherly P., Holtzman, David M., Bales, Kelly R., Gitter, Bruce D., May, Patrick C., Paul, Steven M., DeMattos, Ronald B.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725332/
https://ncbi.nlm.nih.gov/pubmed/15659599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4337-04.2005
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