Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model

Alzheimer's disease (AD) is characterized by the aggregation and deposition of the normally soluble amyloid-β (Aβ) peptide in the extracellular spaces of the brain as parenchymal plaques and in the walls of cerebral vessels as cerebral amyloid angiopathy (CAA). CAA is a common cause of brain he...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Fryer, John D., Simmons, Kelly, Parsadanian, Maia, Bales, Kelly R., Paul, Steven M., Sullivan, Patrick M., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725147/
https://ncbi.nlm.nih.gov/pubmed/15772340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5170-04.2005
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