Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

INTRODUCTION: Amyloid β (Aβ) accumulates in the extracellular space as diffuse and neuritic plaques in Alzheimer’s disease (AD). Aβ also deposits on the walls of arterioles as cerebral amyloid angiopathy (CAA) in most cases of AD and sometimes independently of AD. Apolipoprotein E (apoE) ɛ4 is assoc...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Liao, Fan, Zhang, Tony J., Jiang, Hong, Lefton, Katheryn B., Robinson, Grace O., Vassar, Robert, Sullivan, Patrick M., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641345/
https://ncbi.nlm.nih.gov/pubmed/26556230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0250-y
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