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Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

INTRODUCTION: Amyloid β (Aβ) accumulates in the extracellular space as diffuse and neuritic plaques in Alzheimer’s disease (AD). Aβ also deposits on the walls of arterioles as cerebral amyloid angiopathy (CAA) in most cases of AD and sometimes independently of AD. Apolipoprotein E (apoE) ɛ4 is assoc...

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Bibliografske podrobnosti
izdano v:Acta Neuropathol Commun
Main Authors: Liao, Fan, Zhang, Tony J., Jiang, Hong, Lefton, Katheryn B., Robinson, Grace O., Vassar, Robert, Sullivan, Patrick M., Holtzman, David M.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641345/
https://ncbi.nlm.nih.gov/pubmed/26556230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0250-y
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