Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model

BACKGROUND: CD2-associated protein (CD2AP) is an SH3-containing scaffold adaptor protein which regulates the actin cytoskeleton. Recently, CD2AP was identified as a genetic risk factor for Alzheimer’s disease (AD) by several genome-wide association studies. One of the hallmarks of AD is the accumula...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Neurodegener
Main Authors: Liao, Fan, Jiang, Hong, Srivatsan, Subhashini, Xiao, Qingli, Lefton, Katheryn B, Yamada, Kaoru, Mahan, Thomas E, Lee, Jin-Moo, Shaw, Andrey S, Holtzman, David M
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374406/
https://ncbi.nlm.nih.gov/pubmed/25887956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0006-y
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