Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer’s disease

Transgenic rat models of Alzheimer’s disease were used to examine differences in memory and brain histology. Double transgenic female rats (APP+PS1) over-expressing human amyloid precursor protein (APP) and presenilin 1 (PS1) and single transgenic rats (APP21) over-expressing human APP were compared...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Klakotskaia, Diana, Agca, Cansu, Richardson, Rachel A., Stopa, Edward G., Schachtman, Todd R., Agca, Yuksel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895023/
https://ncbi.nlm.nih.gov/pubmed/29641600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195469
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