Development of transgenic rats producing human β-amyloid precursor protein as a model for Alzheimer's disease: Transgene and endogenous APP genes are regulated tissue-specifically

BACKGROUND: Alzheimer's disease (AD) is a devastating neurodegenerative disorder that affects a large and growing number of elderly individuals. In addition to idiopathic disease, AD is also associated with autosomal dominant inheritance, which causes a familial form of AD (FAD). Some instances...

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Bibliographic Details
Main Authors: Agca, Cansu, Fritz, Jason J, Walker, Lary C, Levey, Allan I, Chan, Anthony WS, Lah, James J, Agca, Yuksel
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268936/
https://ncbi.nlm.nih.gov/pubmed/18302776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-28
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