Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention

BACKGROUND: We previously reported the production of transgenic rats (APP21 line) that over-express human amyloid precursor protein (APP) containing Swedish and Indiana mutations. In order to generate a better model for Alzheimer’s disease (AD), the APP21 rat line was used to generate double transge...

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Detalhes bibliográficos
Publicado no:BMC Neurosci
Main Authors: Agca, Cansu, Klakotskaia, Diana, Schachtman, Todd R., Chan, Anthony W., Lah, James J., Agca, Yuksel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936262/
https://ncbi.nlm.nih.gov/pubmed/27388605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-016-0281-8
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