Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-β Precursor Protein Transgenic Mice

Heparan sulfate (HS) and HS proteoglycans (HSPGs) colocalize with amyloid-β (Aβ) deposits in Alzheimer disease brain and in Aβ precursor protein (AβPP) transgenic mouse models. Heparanase is an endoglycosidase that specifically degrades the unbranched glycosaminoglycan side chains of HSPGs. The aim...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Jendresen, Charlotte B., Cui, Hao, Zhang, Xiao, Vlodavsky, Israel, Nilsson, Lars N. G., Li, Jin-Ping
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335241/
https://ncbi.nlm.nih.gov/pubmed/25548284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600569
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items