Heparanase 2 Interacts with Heparan Sulfate with High Affinity and Inhibits Heparanase Activity

Heparanase activity is highly implicated in cell dissemination associated with tumor metastasis, angiogenesis, and inflammation. Heparanase expression is induced in many hematological and solid tumors, associated with poor prognosis. Heparanase homolog, termed heparanase 2 (Hpa2), was cloned based o...

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Main Authors: Levy-Adam, Flonia, Feld, Sari, Cohen-Kaplan, Victoria, Shteingauz, Anna, Gross, Miriam, Arvatz, Gil, Naroditsky, Inna, Ilan, Neta, Doweck, Ilana, Vlodavsky, Israel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Glycobiology and Extracellular Matrices
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934666/
https://ncbi.nlm.nih.gov/pubmed/20576607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116384
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