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Heparanase 2 Interacts with Heparan Sulfate with High Affinity and Inhibits Heparanase Activity
Heparanase activity is highly implicated in cell dissemination associated with tumor metastasis, angiogenesis, and inflammation. Heparanase expression is induced in many hematological and solid tumors, associated with poor prognosis. Heparanase homolog, termed heparanase 2 (Hpa2), was cloned based o...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2934666/ https://ncbi.nlm.nih.gov/pubmed/20576607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116384 |
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