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Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation: PRECLINICAL AND CLINICAL SIGNIFICANCE IN HEAD AND NECK CANCER
Activity of heparanase is implicated strongly in dissemination of metastatic tumor cells and cells of the immune system. In addition, heparanase enhances the phosphorylation of selected signaling molecules, including SRC and EGFR, in a manner that requires secretion but not enzymatic activity of hep...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307274/ https://ncbi.nlm.nih.gov/pubmed/22194600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.271346 |
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