Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation: PRECLINICAL AND CLINICAL SIGNIFICANCE IN HEAD AND NECK CANCER

Activity of heparanase is implicated strongly in dissemination of metastatic tumor cells and cells of the immune system. In addition, heparanase enhances the phosphorylation of selected signaling molecules, including SRC and EGFR, in a manner that requires secretion but not enzymatic activity of hep...

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Autores principales: Cohen-Kaplan, Victoria, Jrbashyan, Jenny, Yanir, Yoav, Naroditsky, Inna, Ben-Izhak, Ofer, Ilan, Neta, Doweck, Ilana, Vlodavsky, Israel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Glycobiology and Extracellular Matrices
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307274/
https://ncbi.nlm.nih.gov/pubmed/22194600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.271346
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