Heparanase 2 Interacts with Heparan Sulfate with High Affinity and Inhibits Heparanase Activity

Heparanase activity is highly implicated in cell dissemination associated with tumor metastasis, angiogenesis, and inflammation. Heparanase expression is induced in many hematological and solid tumors, associated with poor prognosis. Heparanase homolog, termed heparanase 2 (Hpa2), was cloned based o...

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Bibliographic Details
Main Authors: Levy-Adam, Flonia, Feld, Sari, Cohen-Kaplan, Victoria, Shteingauz, Anna, Gross, Miriam, Arvatz, Gil, Naroditsky, Inna, Ilan, Neta, Doweck, Ilana, Vlodavsky, Israel
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934666/
https://ncbi.nlm.nih.gov/pubmed/20576607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116384
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