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Human Apolipoprotein E4 Alters the Amyloid-β 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model

Alzheimer's disease (AD) is characterized by the aggregation and deposition of the normally soluble amyloid-β (Aβ) peptide in the extracellular spaces of the brain as parenchymal plaques and in the walls of cerebral vessels as cerebral amyloid angiopathy (CAA). CAA is a common cause of brain he...

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Bibliografski detalji
Izdano u:J Neurosci
Glavni autori: Fryer, John D., Simmons, Kelly, Parsadanian, Maia, Bales, Kelly R., Paul, Steven M., Sullivan, Patrick M., Holtzman, David M.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2005
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725147/
https://ncbi.nlm.nih.gov/pubmed/15772340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5170-04.2005
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