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A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system
OBJECTIVE: Accumulation of amyloid-β (Aβ) by over-production or under-clearance in the central nervous system is hypothesized to be a necessary event in the pathogenesis of Alzheimer Disease. However, previously there has not been a method to determine drug effects on Aβ production or clearance in t...
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| Hlavní autoři: | , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2730994/ https://ncbi.nlm.nih.gov/pubmed/19360898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21623 |
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