Deficiency of Aph1B/C-γ-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

Regulated intramembrane proteolysis by γ-secretase cleaves proteins in their transmembrane domain and is involved in important signaling pathways. At least four different γ-secretase complexes have been identified, but little is known about their biological role and specificity. Previous work has de...

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Detalhes bibliográficos
Main Authors: Dejaegere, T., Serneels, L., Schäfer, M. K., Van Biervliet, J., Horré, K., Depboylu, C., Alvarez-Fischer, D., Herreman, A., Willem, M., Haass, C., Höglinger, G. U., D'Hooge, R., De Strooper, B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474502/
https://ncbi.nlm.nih.gov/pubmed/18626010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800507105
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