Deficiency of Aph1B/C-γ-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment

Regulated intramembrane proteolysis by γ-secretase cleaves proteins in their transmembrane domain and is involved in important signaling pathways. At least four different γ-secretase complexes have been identified, but little is known about their biological role and specificity. Previous work has de...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Dejaegere, T., Serneels, L., Schäfer, M. K., Van Biervliet, J., Horré, K., Depboylu, C., Alvarez-Fischer, D., Herreman, A., Willem, M., Haass, C., Höglinger, G. U., D'Hooge, R., De Strooper, B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474502/
https://ncbi.nlm.nih.gov/pubmed/18626010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800507105
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi