The β-Secretase BACE1 in Alzheimer’s Disease

BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ(42), which aggregates into bioactive conformational species and likely initiates toxicity in Alzheime...

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Bibliografske podrobnosti
izdano v:Biol Psychiatry
Main Authors: Hampel, Harald, Vassar, Robert, De Strooper, Bart, Hardy, John, Willem, Michael, Singh, Neeraj, Zhou, John, Yan, Riqiang, Vanmechelen, Eugeen, De Vos, Ann, Nisticò, Robert, Corbo, Massimo, Imbimbo, Bruno Pietro, Streffer, Johannes, Voytyuk, Iryna, Timmers, Maarten, Monfared, Amir Abbas Tahami, Irizarry, Michael, Albala, Bruce, Koyama, Akihiko, Watanabe, Naoto, Kimura, Teiji, Yarenis, Lisa, Lista, Simone, Kramer, Lynn, Vergallo, Andrea
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533042/
https://ncbi.nlm.nih.gov/pubmed/32223911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2020.02.001
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