β-Secretase1 biological markers for Alzheimer’s disease: state-of-art of validation and qualification

β-Secretase1 (BACE1) protein concentrations and rates of enzyme activity, analyzed in human bodily fluids, are promising candidate biological markers for guidance in clinical trials investigating BACE1 inhibitors to halt or delay the dysregulation of the amyloid-β pathway in Alzheimer’s disease (AD)...

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Dades bibliogràfiques
Publicat a:Alzheimers Res Ther
Autors principals: Hampel, Harald, Lista, Simone, Vanmechelen, Eugeen, Zetterberg, Henrik, Giorgi, Filippo Sean, Galgani, Alessandro, Blennow, Kaj, Caraci, Filippo, Das, Brati, Yan, Riqiang, Vergallo, Andrea
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566058/
https://ncbi.nlm.nih.gov/pubmed/33066807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00686-3
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