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Targeting the β secretase BACE1 for Alzheimer’s disease therapy
The β secretase, widely known as β-site amyloid precursor protein cleaving enzyme 1 (BACE1), initiates the production of the toxic amyloid β (Aβ) that plays a crucial early part in Alzheimer’s disease pathogenesis. BACE1 is a prime therapeutic target for lowering cerebral Aβ concentrations in Alzhei...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086426/ https://ncbi.nlm.nih.gov/pubmed/24556009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(13)70276-X |
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