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The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

The β-amyloid (Aβ) peptide is the major constituent of amyloid plaques in Alzheimer's disease (AD) brain and is likely to play a central role in the pathogenesis of this devastating neurodegenerative disorder. The β-secretase, β-site amyloid precursor protein cleaving enzyme (BACE1; also called...

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Sonraí Bibleagrafaíochta
Main Authors: Vassar, Robert, Kovacs, Dora M., Yan, Riqiang, Wong, Philip C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879048/
https://ncbi.nlm.nih.gov/pubmed/19828790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3657-09.2009
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