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The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease
Amyloid plaques are defining histopathologic lesions in the brains of Alzheimer's disease (AD) patients and are composed of the amyloid-beta peptide, which is widely considered to play a critical role in the pathogenesis of AD. The β-secretase, or β-site amyloid precursor protein cleaving enzym...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3226309/ https://ncbi.nlm.nih.gov/pubmed/21639952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt82 |
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