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Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration
γ‐Secretases are a family of intramembrane cleaving aspartyl proteases and important drug targets in Alzheimer's disease. Here, we generated mice deficient for all γ‐secretases in the pyramidal neurons of the postnatal forebrain by deleting the three anterior pharynx defective 1 (Aph1) subunits...
Enregistré dans:
| Publié dans: | EMBO Mol Med |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5538297/ https://ncbi.nlm.nih.gov/pubmed/28588032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707561 |
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