Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

γ‐Secretases are a family of intramembrane cleaving aspartyl proteases and important drug targets in Alzheimer's disease. Here, we generated mice deficient for all γ‐secretases in the pyramidal neurons of the postnatal forebrain by deleting the three anterior pharynx defective 1 (Aph1) subunits...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Acx, Hermien, Serneels, Lutgarde, Radaelli, Enrico, Muyldermans, Serge, Vincke, Cécile, Pepermans, Elise, Müller, Ulrike, Chávez‐Gutiérrez, Lucía, De Strooper, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538297/
https://ncbi.nlm.nih.gov/pubmed/28588032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707561
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