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Probing γ‐secretase–substrate interactions at the single amino acid residue level
Intramembrane proteolysis by γ‐secretases plays major roles in disease pathology and cellular signalling, yet the dynamics of these enzyme complexes and how they recognize substrates remains poorly understood. New work in The EMBO Journal utilizes photo‐affinity cross‐linking to map APP interactions...
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| 發表在: | EMBO J |
|---|---|
| Main Authors: | , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
John Wiley and Sons Inc.
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4969572/ https://ncbi.nlm.nih.gov/pubmed/27370209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694978 |
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