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Functional and Topological Analysis of Pen-2, the Fourth Subunit of the γ-Secretase Complex

The γ-secretase complex is a member of the family of intramembrane cleaving proteases, involved in the generation of the Aβ peptides in Alzheimer disease. One of the four subunits of the complex, presenilin, harbors the catalytic site, although the role of the other three subunits is less well under...

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Detalhes bibliográficos
Main Authors: Bammens, Leen, Chávez-Gutiérrez, Lucía, Tolia, Alexandra, Zwijsen, An, De Strooper, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069430/
https://ncbi.nlm.nih.gov/pubmed/21296884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.216978
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