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Functional and Topological Analysis of Pen-2, the Fourth Subunit of the γ-Secretase Complex
The γ-secretase complex is a member of the family of intramembrane cleaving proteases, involved in the generation of the Aβ peptides in Alzheimer disease. One of the four subunits of the complex, presenilin, harbors the catalytic site, although the role of the other three subunits is less well under...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069430/ https://ncbi.nlm.nih.gov/pubmed/21296884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.216978 |
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