Presenilins Form ER Ca(2+) Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder. Mutations in presenilins 1 and 2 (PS1 and PS2) account for ∼40% of familial AD (FAD) cases. FAD mutations and genetic deletions of presenilins have been associated with calcium (Ca(2+)) signaling abnormalitie...

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Autors principals: Tu, Huiping, Nelson, Omar, Bezprozvanny, Arseny, Wang, Zhengnan, Lee, Sheu-Fen, Hao, Yi-Heng, Serneels, Lutgarde, De Strooper, Bart, Yu, Gang, Bezprozvanny, Ilya
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241869/
https://ncbi.nlm.nih.gov/pubmed/16959576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.06.059
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