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Presenilins function in ER calcium leak and Alzheimer’s disease pathogenesis

Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD brain are thought to trigger the extensive synaptic loss and neurodegeneration linked to cognitive decline, an idea that u...

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Bibliographische Detailangaben
Hauptverfasser: Supnet, Charlene, Bezprozvanny, Ilya
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172403/
https://ncbi.nlm.nih.gov/pubmed/21663966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2011.05.013
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