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Presenilins function in ER calcium leak and Alzheimer’s disease pathogenesis
Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD brain are thought to trigger the extensive synaptic loss and neurodegeneration linked to cognitive decline, an idea that u...
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Main Authors: | , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172403/ https://ncbi.nlm.nih.gov/pubmed/21663966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2011.05.013 |
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