BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells

Amyloids are often associated with pathologic processes such as in Alzheimer’s disease (AD), but can also underlie physiological processes such as pigmentation. Formation of pathological and functional amyloidogenic substrates can require precursor processing by proteases, as exemplified by the gene...

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Bibliographische Detailangaben
Hauptverfasser: Rochin, Leila, Hurbain, Ilse, Serneels, Lutgarde, Fort, Cecile, Watt, Brenda, Leblanc, Pascal, Marks, Michael S., De Strooper, Bart, Raposo, Graça, van Niel, Guillaume
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696817/
https://ncbi.nlm.nih.gov/pubmed/23754390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220748110
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