N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils

Pmel17 is a transmembrane protein that mediates the early steps in the formation of melanosomes, the subcellular organelles of melanocytes in which melanin pigments are synthesized and stored. In melanosome precursor organelles, proteolytic fragments of Pmel17 form insoluble, amyloid-like fibrils up...

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Detalhes bibliográficos
Main Authors: Watt, Brenda, van Niel, Guillaume, Fowler, Douglas M., Hurbain, Ilse, Luk, Kelvin C., Stayrook, Steven E., Lemmon, Mark A., Raposo, Graça, Shorter, James, Kelly, Jeffery W., Marks, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790984/
https://ncbi.nlm.nih.gov/pubmed/19840945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047449
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