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N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils

Pmel17 is a transmembrane protein that mediates the early steps in the formation of melanosomes, the subcellular organelles of melanocytes in which melanin pigments are synthesized and stored. In melanosome precursor organelles, proteolytic fragments of Pmel17 form insoluble, amyloid-like fibrils up...

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Main Authors: Watt, Brenda, van Niel, Guillaume, Fowler, Douglas M., Hurbain, Ilse, Luk, Kelvin C., Stayrook, Steven E., Lemmon, Mark A., Raposo, Graça, Shorter, James, Kelly, Jeffery W., Marks, Michael S.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790984/
https://ncbi.nlm.nih.gov/pubmed/19840945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.047449
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