Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression

The human growth hormone (hGH) minigene is frequently used in the derivation of transgenic mouse lines to enhance transgene expression. Although this minigene is present in the transgenes as a second-cistron, and thus not thought to be expressed, we found that three commonly used lines, Pdx1-Cre(Lat...

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Publicado no:Cell Metab
Main Authors: Brouwers, Bas, de Faudeur, Geoffroy, Osipovich, Anna B., Goyvaerts, Lotte, Lemaire, Katleen, Boesmans, Leen, Cauwelier, Elisa J.G., Granvik, Mikaela, Pruniau, Vincent P.E.G., Van Lommel, Leentje, Van Schoors, Jolien, Stancill, Jennifer S., Smolders, Ilse, Goffin, Vincent, Binart, Nadine, Veld, Peter in’t, Declercq, Jeroen, Magnuson, Mark A., Creemers, John W.M., Schuit, Frans, Schraenen, Anica
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674787/
https://ncbi.nlm.nih.gov/pubmed/25470546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.11.004
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