Role of furin in granular acidification in the endocrine pancreas: Identification of the V-ATPase subunit Ac45 as a candidate substrate

Furin is a proprotein convertase which activates a variety of regulatory proteins in the constitutive exocytic and endocytic pathway. The effect of genetic ablation of fur was studied in the endocrine pancreas to define its physiological function in the regulated secretory pathway. Pdx1-Cre/loxP fur...

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Detalhes bibliográficos
Main Authors: Louagie, Els, Taylor, Neil A., Flamez, Daisy, Roebroek, Anton J. M., Bright, Nicholas A., Meulemans, Sandra, Quintens, Roel, Herrera, Pedro L., Schuit, Frans, Van de Ven, Wim J. M., Creemers, John W. M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527909/
https://ncbi.nlm.nih.gov/pubmed/18713856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800340105
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