Latent Transforming Growth Factor β-Binding Proteins-2 and -3 Inhibit the Proprotein Convertase 5/6A

The basic amino acid-specific proprotein convertase 5/6 (PC5/6) is an essential secretory protease, as knock-out mice die at birth and exhibit multiple homeotic transformation defects, including impaired bone morphogenesis and lung structure. Some of the observed defects were attributed to impaired...

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Bibliographic Details
Main Authors: Sun, Xiaowei, Essalmani, Rachid, Susan-Resiga, Delia, Prat, Annik, Seidah, Nabil G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190714/
https://ncbi.nlm.nih.gov/pubmed/21700711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.242479
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