Thrombin activation of protein C requires prior processing by a liver proprotein convertase

Protein C, a secretory vitamin K-dependent anticoagulant serine protease, inactivates factors Va/VIIIa. It is exclusively synthesized in liver hepatocytes as an inactive zymogen (proprotein C). In humans, thrombin cleavage of the propeptide at PR(221)↓ results in activated protein C (APC; residues 2...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Essalmani, Rachid, Susan-Resiga, Delia, Guillemot, Johann, Kim, Woojin, Sachan, Vatsal, Awan, Zuhier, Chamberland, Ann, Asselin, Marie-Claude, Ly, Kévin, Desjardins, Roxane, Day, Robert, Prat, Annik, Seidah, Nabil G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481563/
https://ncbi.nlm.nih.gov/pubmed/28468828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770040
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