Furin Is the Major Processing Enzyme of the Cardiac-specific Growth Factor Bone Morphogenetic Protein 10

Bone morphogenetic protein 10 (BMP10) is a member of the TGF-β superfamily and plays a critical role in heart development. In the postnatal heart, BMP10 is restricted to the right atrium. The inactive pro-BMP10 (∼60 kDa) is processed into active BMP10 (∼14 kDa) by an unknown protease. Proteolytic cl...

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Bibliografiske detaljer
Main Authors: Susan-Resiga, Delia, Essalmani, Rachid, Hamelin, Josée, Asselin, Marie-Claude, Benjannet, Suzanne, Chamberland, Ann, Day, Robert, Szumska, Dorota, Constam, Daniel, Bhattacharya, Shoumo, Prat, Annik, Seidah, Nabil G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123046/
https://ncbi.nlm.nih.gov/pubmed/21550985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.233577
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