Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation

Single domain antibodies (sdAbs) correspond to the antigen-binding domains of camelid antibodies. They have the same antigen-binding properties and specificity as monoclonal antibodies (mAbs) but are easier and cheaper to produce. We report here the development of sdAbs targeting human PCSK9 (propro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Weider, Elodie, Susan-Resiga, Delia, Essalmani, Rachid, Hamelin, Josée, Asselin, Marie-Claude, Nimesh, Surendra, Ashraf, Yahya, Wycoff, Keith L., Zhang, Jianbing, Prat, Annik, Seidah, Nabil G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2016
Pynciau:
Lipids
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974380/
https://ncbi.nlm.nih.gov/pubmed/27284008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.717736
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