Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation

Single domain antibodies (sdAbs) correspond to the antigen-binding domains of camelid antibodies. They have the same antigen-binding properties and specificity as monoclonal antibodies (mAbs) but are easier and cheaper to produce. We report here the development of sdAbs targeting human PCSK9 (propro...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Weider, Elodie, Susan-Resiga, Delia, Essalmani, Rachid, Hamelin, Josée, Asselin, Marie-Claude, Nimesh, Surendra, Ashraf, Yahya, Wycoff, Keith L., Zhang, Jianbing, Prat, Annik, Seidah, Nabil G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Lipids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974380/
https://ncbi.nlm.nih.gov/pubmed/27284008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.717736
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky