Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation

Single domain antibodies (sdAbs) correspond to the antigen-binding domains of camelid antibodies. They have the same antigen-binding properties and specificity as monoclonal antibodies (mAbs) but are easier and cheaper to produce. We report here the development of sdAbs targeting human PCSK9 (propro...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Weider, Elodie, Susan-Resiga, Delia, Essalmani, Rachid, Hamelin, Josée, Asselin, Marie-Claude, Nimesh, Surendra, Ashraf, Yahya, Wycoff, Keith L., Zhang, Jianbing, Prat, Annik, Seidah, Nabil G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974380/
https://ncbi.nlm.nih.gov/pubmed/27284008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.717736
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