In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9

The proprotein convertase PCSK9 plays a key role in cholesterol homeostasis by binding the LDL receptor and targeting it toward degradation. PCSK9 is strongly expressed in the liver and is found in human and mouse plasma as mature (∼62 kDa) and inactivated (∼55 kDa) forms. Ex vivo data showed that h...

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Hlavní autoři: Essalmani, Rachid, Susan-Resiga, Delia, Chamberland, Ann, Abifadel, Marianne, Creemers, John W., Boileau, Catherine, Seidah, Nabil G., Prat, Annik
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039354/
https://ncbi.nlm.nih.gov/pubmed/21147780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192104
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