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PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in cholesterol homeostasis through enhanced degradation of the LDL receptor (LDLR) in liver. As novel inhibitors/silencers of PCSK9 are now being tested in clinical trials to treat hypercholesterolemia, it is crucial to define...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3111744/ https://ncbi.nlm.nih.gov/pubmed/21518694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M014118 |
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