PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in cholesterol homeostasis through enhanced degradation of the LDL receptor (LDLR) in liver. As novel inhibitors/silencers of PCSK9 are now being tested in clinical trials to treat hypercholesterolemia, it is crucial to define...

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Detaylı Bibliyografya
Asıl Yazarlar: Rousselet, Estelle, Marcinkiewicz, Jadwiga, Kriz, Jasna, Zhou, Ann, Hatten, Mary E., Prat, Annik, Seidah, Nabil G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Biochemistry and Molecular Biology 2011
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Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111744/
https://ncbi.nlm.nih.gov/pubmed/21518694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M014118
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