The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol

Por Poirier, Steve, Mayer, Gaétan
Publicado em 2013

Effects of LDL Receptor Modulation on Lymphatic Function

Por Milasan, Andreea, Dallaire, François, Mayer, Gaétan, Martel, Catherine
Publicado no Sci Rep (2016)

Combined Effects of Rosuvastatin and Exercise on Gene Expression of Key Molecules Involved in Cholesterol Metabolism in Ovariectomized Rats

Por Ngo Sock, Emilienne Tudor, Mayer, Gaétan, Lavoie, Jean-Marc
Publicado no PLoS One (2016)

Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain

Por Poirier, Steve, Hamouda, Hocine Ait, Villeneuve, Louis, Demers, Annie, Mayer, Gaétan
Publicado no PLoS One (2016)

The Anti-Hypercholesterolemic Effect of Low p53 Expression Protects Vascular Endothelial Function in Mice

Por Leblond, Francois, Poirier, Steve, Yu, Carol, Duquette, Natacha, Mayer, Gaetan, Thorin, Eric
Publicado em 2014

Proteolytic cleavage of the hydrophobic domain in the Ca(V)α2δ1 subunit improves assembly and activity of cardiac Ca(V)1.2 channels

Por Segura, Emilie, Bourdin, Benoîte, Tétreault, Marie-Philippe, Briot, Julie, Allen, Bruce G., Mayer, Gaétan, Parent, Lucie
Publicado no J Biol Chem (2017)

The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins

Por Poirier, Steve, Mayer, Gaétan, Murphy, Stephanie R., Garver, William S., Chang, Ta Yuan, Schu, Peter, Seidah, Nabil G.
Publicado em 2013

The Cysteine-rich Domain of the Secreted Proprotein Convertases PC5A and PACE4 Functions as a Cell Surface Anchor and Interacts with Tissue Inhibitors of Metalloproteinases

Por Nour, Nadia, Mayer, Gaétan, Mort, John S., Salvas, Alexandre, Mbikay, Majambu, Morrison, Charlotte J., Overall, Christopher M., Seidah, Nabil G.
Publicado em 2005

The Epigenetic Drug 5-Azacytidine Interferes with Cholesterol and Lipid Metabolism

Por Poirier, Steve, Samami, Samaneh, Mamarbachi, Maya, Demers, Annie, Chang, Ta Yuan, Vance, Dennis E., Hatch, Grant M., Mayer, Gaétan
Publicado em 2014

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

Por Seidah, Nabil G., Poirier, Steve, Denis, Maxime, Parker, Rex, Miao, Bowman, Mapelli, Claudio, Prat, Annik, Wassef, Hanny, Davignon, Jean, Hajjar, Katherine A., Mayer, Gaétan
Publicado em 2012

Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation: EVIDENCE FOR AN INTRACELLULAR ROUTE

Por Poirier, Steve, Mayer, Gaetan, Poupon, Viviane, McPherson, Peter S., Desjardins, Roxane, Ly, Kevin, Asselin, Marie-Claude, Day, Robert, Duclos, Franck J., Witmer, Mark, Parker, Rex, Prat, Annik, Seidah, Nabil G.
Publicado em 2009

Effects of the Prosegment and pH on the Activity of PCSK9: EVIDENCE FOR ADDITIONAL PROCESSING EVENTS

Por Benjannet, Suzanne, Luna Saavedra, Yascara Grisel, Hamelin, Josée, Asselin, Marie-Claude, Essalmani, Rachid, Pasquato, Antonella, Lemaire, Peter, Duke, Gerald, Miao, Bowman, Duclos, Franck, Parker, Rex, Mayer, Gaétan, Seidah, Nabil G.
Publicado em 2010

Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other

Por Butkinaree, Chutikarn, Canuel, Maryssa, Essalmani, Rachid, Poirier, Steve, Benjannet, Suzanne, Asselin, Marie-Claude, Roubtsova, Anna, Hamelin, Josée, Marcinkiewicz, Jadwiga, Chamberland, Ann, Guillemot, Johann, Mayer, Gaétan, Sisodia, Sangram S., Jacob, Yves, Prat, Annik, Seidah, Nabil G.
Publicado no J Biol Chem (2015)