The Cysteine-rich Domain of the Secreted Proprotein Convertases PC5A and PACE4 Functions as a Cell Surface Anchor and Interacts with Tissue Inhibitors of Metalloproteinases

The proprotein convertases PC5, PACE4 and furin contain a C-terminal cysteine-rich domain (CRD) of unknown function. We demonstrate that the CRD confers to PC5A and PACE4 properties to bind tissue inhibitors of metalloproteinases (TIMPs) and the cell surface. Confocal microscopy and biochemical anal...

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Xehetasun bibliografikoak
Egile Nagusiak: Nour, Nadia, Mayer, Gaétan, Mort, John S., Salvas, Alexandre, Mbikay, Majambu, Morrison, Charlotte J., Overall, Christopher M., Seidah, Nabil G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Cell Biology 2005
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1266420/
https://ncbi.nlm.nih.gov/pubmed/16135528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-06-0504
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