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The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions
The secretory proprotein convertase (PC) family comprises nine members: PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9. The first seven PCs cleave their substrates at single or paired basic residues, and SKI-1/S1P cleaves its substrates at non-basic residues in the Golgi. PCSK9 clea...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3724608/ https://ncbi.nlm.nih.gov/pubmed/23775089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R113.481549 |
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